Anti-Anxiety Evaluation

Are you looking for a reliable partner to help you evaluate the potential of your dietary supplements/probiotics in anti-anxiety? Creative Biogene Zebrafish Platform is the best choice for you. We extend a suite of scientific evaluations of anti-anxiety efficacy for your dietary supplements/probiotics. Our platform offers integrated approaches, combining advanced methodologies and expert analysis to deliver reliable results, empowering you with the necessary evidence to confidently showcase the anti-anxiety claim of your products. So why wait? Contact us now to learn more about our anti-anxiety services and how they can benefit your dietary supplements development.

Anxiety disorder is a complex psychiatric condition characterized by intense and persistent feelings of excessive worry, fear, and dread. With the rise of urbanization and lifestyle changes, anxiety disorder has become increasingly prevalent, posing a significant challenge to public health. So, it is a problem that needs to be solved urgently in public health due to the complex pathogenesis and difficult clinical medication of anxiety.

Zebrafish (Danio rerio) is a popular and valuable species used in many different biomedical research areas. Zebrafish neurotransmitter systems develop during embryogenesis and are functional in larvae. The brain, vascular system, liver, kidneys, and intestines are fully developed and functional on day 2 after hatching. These findings highlight the similarities between neurochemistry and behavior in mammals and fish, that allow the use of zebrafish in behavioral models of anxiety.

Our Zebrafish-based Scientific Evaluation of Anti-Anxiety Efficacy

Recent research has shown that mCPP, a non-specific 5-hydroxytryptaminergic agonist, can induce anxiety by affecting the 5-HT pathway.

At Creative Biogene, we conduct rigorous experiments to evaluate the anti-anxiety potential of your dietary supplements/probiotics by inducing anxiety in zebrafish using mCPP. We carefully divide zebrafish into three groups, including a vehicle control group, a model group, and a dietary supplement/probiotic group, to ensure accurate results. The vehicle control group remains untreated, while both the model group and dietary supplement/probiotic group ingest equal amounts of mCPP by dissolving it into water. After adding your products, we evaluate various indicators to discover the relationship between your products and anxiety. Details are as follows.

Example Data

Fig. 1 Trace map of first phase behavior test

Fig. 2 Moving distance of zebrafish in each group (n = 10)

If you are interested in our services, please do not hesitate to contact us at any time or submit an inquiry to us directly. We are looking forward to cooperating with you.

Reference

1. Zhao, B.; et al. Nutrient combinations exhibit universal antianxiety, antioxidant, neuro-protecting, and memory-improving activities. Frontiers in Nutrition. 2023, 9: 996692.

For research use only. Not intended for any clinical use.