Constipation Relief Evaluation

Are you looking for a reliable and effective way to evaluate the potential of your dietary supplements/probiotics to relieve constipation? Look no further than Creative Biogene Zebrafish Platform! Our team of experts specializes in the scientific evaluation of health claims, and we've established a stable model that can help you recognize the relationship between your dietary supplements/probiotics and constipation. With our services, you can rest assured that you'll receive accurate and trustworthy results that can help you make informed decisions about your products.

Most healthy adults have bowel movements three times a day to three times a week. Constipation, on the other hand, refers to infrequent bowel movements, or when the stool is hard, dry, and difficult to pass. This common condition can be quite uncomfortable, leading to discomfort and stress for those who experience it. In light of this, more and more people are turning to dietary supplements/probiotics as a way of relieving constipation. These supplements aim to improve bowel movements by softening stools, stimulating the digestive system, and promoting regularity.

Our Zebrafish-based Scientific Evaluation of Constipation Relief

Aluminum sulfate can reduce intestinal motility and cause constipation in zebrafish. At Creative Biogene, we divide zebrafish into three distinct groups: a vehicle control group, a model group, and a dietary supplement/probiotic group. The dietary supplement/probiotic group is given your products in advance before all three groups are administered Nile Red to visualize intestinal motility. Subsequently, both the model group and the dietary supplement/probiotic group are given an equal amount of aluminum sulfate. The potential of the dietary supplement/probiotic to promote intestinal motility is evaluated by observing the fluorescence intensity of the zebrafish intestines under a fluorescence microscope.

Fig. 1 Nile red fluorescence staining in zebrafish

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For research use only. Not intended for any clinical use.