Anti-Acne Efficacy Evaluation

If you are looking for a reliable and efficient way to conduct anti-acne efficacy evaluation of your cosmetic products, Creative Biogene Zebrafish Platform offers an excellent solution. With our anti-acne efficacy evaluation, we can help you assess the effectiveness of your products and provide valuable insights that can be used to improve your products' development.

Globally, acne is a widespread and chronic inflammatory condition affecting the pilosebaceous follicles. It is estimated to affect 9.4% of the global population, making it the eighth most prevalent skin disease. Acne is particularly prevalent among teenagers, with over 85% experiencing the condition. Genetics, environmental variables, nutrition, hormonal state, stress, smoking, and comedogenic medicines such as androgens, halogens, corticosteroids, and bacteria can all contribute to the development, worsening, or exacerbation of acne. Due to the impact of acne on individuals and its associated social and psychological effects, the development of anti-acne cosmetics has become increasingly important.

Fig. 1 Schematic illustration of healthy/normal skin tissue vs acne inflamed skin tissue, various factors contributing to the formation and development of acne.

Our Zebrafish-based Anti-Acne Efficacy Evaluation

Propionibacterium acnes is a type of bacteria that is closely associated with the development of acne. Studies have shown that it plays a specific role in promoting the release of inflammatory mediators.

At Creative Biogene, we induce inflammatory response by injecting Propionibacterium acnes into transgenic neutrophil green fluorescent strain of zebrafish (MPX). After incubating your cosmetics and zebrafish for a period of time, zebrafish is placed under a fluorescence microscope and photographed to count the number of neutrophils in the yolk sac.

Creative Biogene Zebrafish Platform is backed by a dedicated team of technical experts who offer tailored solutions, ensuring the delivery of high-quality and efficient services. We provide the necessary data support for the efficacy of cosmetics, while also meeting the stringent safety and efficacy testing requirements of various types of cosmetics. Should you have any queries, feel free to reach out to us at any time or submit an inquiry directly. We are eager to forge a partnership with you and look forward to the opportunity to improve further.

Reference

1. Vasam, M.; Korutla, S.; et al. Acne vulgaris: A review of the pathophysiology, treatment, and recent nanotechnology based advances. Biochemistry and Biophysics Reports, 2023, 36: 101578.

For research use only. Not intended for any clinical use.