Vision Protection Evaluation

Creative Biogene Zebrafish Platform is dedicated to offering our clients a dependable and consistent model to evaluate the potential of dietary supplements in vision protection. With our exceptional services, you can market your products with confidence and earn the trust of your target consumers.

Visual impairment is a critical issue that affects a significant portion of the global population. According to recent reports, the number of people with moderate to severe visual impairment is increasing at an alarming rate. As a result, the demand for effective solutions to address this issue has surged, leading to the emergence of various dietary supplements that claim to protect and improve vision. However, manufacturers need to conduct extensive scientific experiments to validate the efficacy of their products and strengthen their market presence.

Despite the obvious morphological differences in the visual system, zebrafish shares a similar architecture and components of the same embryonic origin as humans. The zebrafish retina has the same layered structure and cell types with similar metabolic and phototransduction support as humans. Moreover, zebrafish demonstrates visual responsiveness as early as 72 hours post fertilization (hpf), at which point its retinal structure and function closely resemble that of adult humans. Consequently, the zebrafish represents a valuable tool for the exploration of vision-related research.

Fig. 1 Cross-sectional view of the human and zebrafish retina indicating the similar structural features of the retinal layers

Our Zebrafish-based Scientific Evaluation of Vision Protection

At Creative Biogene, we use mycophenolate mofetil to induce apoptosis in zebrafish eye cells to mimic human ocular diseases. We divide zebrafish into three groups, including a vehicle control group, a model group, and a dietary supplement group. Both the model and dietary supplement groups are given equal amounts of mycophenolate mofetil. After adding your dietary supplements for a while, we observe apoptosis by apoptosis-specific staining of the zebrafish eye. In addition, we also make pathological sections to observe the pathological structural changes in the eye.

Creative Biogene Zebrafish Platform has the expertise and experience to help you conduct the scientific evaluation of health claims about your dietary supplements. Contact us now to discuss your goals and how we can achieve them.

Reference

1. Hong, Y.; Luo Y. Zebrafish model in ophthalmology to study disease mechanism and drug discovery. Pharmaceuticals, 2021, 14(8): 716.

For research use only. Not intended for any clinical use.