Skin Firming Efficacy Evaluation

Creative Biogene Zebrafish Platform, a professional zebrafish platform, is dedicated to providing professional skin firming efficacy evaluation based on zebrafish for our customers and issuing reliable cosmetics efficacy evaluation reports.

Firm skin is taut skin, with good elasticity. And taut, bouncy skin has always been a defining trait of youthful-looking complexions. However, firm skin is something we lose with age, bringing forward the appearance of wrinkles and fine lines. Firm skin is determined by two key structural proteins: collagen and elastin.

• Collagen

Collagen, which makes up about 30% of the body's protein content, supports the skin's firmness and is highest in the skin in the 20s. Beyond this age period, the function of fibroblasts in the dermis slows down, resulting in a gradual decline in collagen production. Simultaneously, glycation affects collagen and causes the skin to deteriorate, thereby resulting in the loss of firmness, elasticity, and the development of wrinkles and sagging skin.

• Elastin

Elastin is a vital protein found in the skin, composed of crosslinked tropoelastin. It binds with microfibrils to create elastic fibers, which provide stretch and recoil to the skin. Age-related reduction in elastin production and damage to elastin have a substantial impact on the skin's appearance, resulting in looser, sagging, and fragile skin.

Fig. 1 The production of collagen fibers in the dermis.

As we age, the firmness of skin decreases significantly, resulting in wrinkles and fine lines. And while these skin concerns are a fact of life, the right skincare products and expert tips can help boost skin firmness. As a result, the cosmetic industry continues to explore ingredients for skin tightening. It is crucial to use effective and appropriate methods to evaluate the skin firming efficacy of cosmetics prior to their availability to consumers.

Our Zebrafish-based Skin Firming Evaluation

In zebrafish, the elastin is encoded by the genes Eln1 and Eln2, and the expression levels of these genes will impact the degree of skin firmness. At Creative Biogene, the expression of Eln1 and Eln2 in zebrafish is detected by qPCR, comparing the changes in elastin gene expression between the treatment group and the control group, to evaluate the skin firming efficacy of cosmetics.

Creative Biogene has advanced testing equipment and a professional team to offer professional solutions and efficient, high-quality services. We provide accurate data support for the efficacy test ensuring compliance with efficacy testing requirements for all categories of cosmetics. If you are interested in our services, please do not hesitate to contact us at any time. We are looking forward to cooperating with you.

References

1. Leslie, B., et al. Clinical relevance of elastin in the structure and function of skin. Aesthetic Surgery Journal Open Forum, 2021, 3.
2. Reilly, D.M.; Lozano, J. Skin collagen through the life stages: Importance for skin health and beauty. Plast. Aesthetic Res, 2021, 8(2).

For research use only. Not intended for any clinical use.