Anti-Glycation Efficacy Evaluation
Creative Biogene Zebrafish Platform can provide professional anti-glycation efficacy evaluation for cosmetic industry players. Through rational analysis and scientific evaluation of cosmetic efficacy, it provides a scientific foundation for cosmetic efficacy claims and registration.
Skin aging is a result of skin damage over the years due to the effects of endogenous and environmental factors. Glycation is one of the processes that cause skin aging. Glycation is a process that is caused by the excessive of glucose in skin fibers. The excess triggers an internal reaction where sugar molecules bind to the collagen and elastin proteins, which are responsible for maintaining the skin's firmness and elasticity. In this process, something called advanced glycation end-products (AGEs) are generated. Over time, these end-products make collagen rigid, causing it to lose its ability to keep the skin supple, ultimately leading to premature signs of aging.
Fig. 1 Effects of AGEs on skin
Our Zebrafish-based Anti-Glycation Efficacy Evaluation
Conventional AGEs exhibit fluorescent characteristics. At Creative Biogene, we utilize glucose and bovine serum albumin to induce glycation reaction to generate AGEs for modeling purposes. After adding your cosmetics, we evaluate the inhibition level of AGEs by fluorescence quantification to reflect their anti-glycation efficacy. Details are as follows.
| Group Setting | Vehicle control group Model group Positive control group Three dose groups of the test cosmetic |
| Analysis Method | Detect the fluorescence intensity of AGEs at 370nm/440nm |
| Data Delivery | Histogram: AGEs fluorescence intensity Written report available on request |
Creative Biogene Zebrafish Platform is a professional organization specializing in cosmetic efficacy evaluation, equipped with a dedicated laboratory for cosmetic efficacy evaluation, aiming to deliver professional cosmetic efficacy studies services to brands and raw material suppliers. If you are interested in our services, please feel free to contact us at any time or submit an inquiry to us directly. We are looking forward to cooperating with you.
Reference
- Gkogkolou, P., et al. Advanced glycation end products: key players in skin aging? Dermato-endocrinology. 2012, 4(3): 259-270.
For research use only. Not intended for any clinical use.
