Prevention of Alcoholic Fatty Liver

If you are seeking a reliable partner to assess the potential of your dietary supplements in preventing alcoholic fatty liver, Creative Biogene Zebrafish Platform is the optimal choice for you. As a distinguished provider for scientific evaluation of health claims, we are dedicated to delivering top-notch data to support the effect of your dietary supplements in preventing alcoholic fatty liver. By leveraging our precise and dependable data, you can give your products a distinct edge in a fiercely competitive market and earn the trust of consumers.

The liver, one of the most important organs in the human body, performs numerous vital functions, including metabolic, vascular, immunological, secretory, and excretory activities. Numerous substances have been shown to be toxic to liver cells, with alcohol being the most widely reported cause of liver disease globally. Alcoholic liver disease (ALD) is a significant contributor to liver disease worldwide, spanning a spectrum of hepatic pathological states from simple steatosis to progressive fibrosis, cirrhosis, and even liver cancer. With the increasing demand, there are many anti-alcoholic liver protection dietary supplements available in the market today.

Our Zebrafish-based Scientific Evaluation for Prevention of Alcoholic Fatty Liver

At Creative Biogene, we have successfully established a stable alcoholic fatty liver model in zebrafish through the administration of alcohol. We divide zebrafish into three groups, including a vehicle control group, a model group and a dietary supplement group.

In order to evaluate your dietary supplements' potential for prevention of alcoholic fatty liver, we incubate the zebrafish with your dietary supplements for a period of time. Subsequently, we collect the zebrafish samples for fat-specific staining and H&E staining. These staining methods allow us to visualize and evaluate the accumulation of fat in zebrafish. Details are as follows.

Example Data

Fig. 1 Hesperidin reduced hepatic steatosis in zebrafish larvae induced by alcohol. (A) Oil Red O staining for whole body of zebrafish larvae. (B) H&E staining for liver sections of zebrafish larvae.

If you want more information about our services or have any other questions, please feel free to contact us at any time or submit an inquiry to us directly. We are looking forward to cooperating with you.

Reference

1. Zhou, Z.; et al. Hesperidin protects against acute alcoholic injury through improving lipid metabolism and cell damage in zebrafish larvae. Evidence-based Complementary and Alternative Medicine, 2017, 2017.

For research use only. Not intended for any clinical use.