- Zebrafish Germ Cell Tumor Models
- Zebrafish Intestinal Cancer Models
- Zebrafish Intrahepatic Cholangiocarcinoma Models
- Zebrafish Liver Cancer Models
- Zebrafish Melanoma Models
- Zebrafish Neurofibromatosis Type 1 Models
- Zebrafish Pancreatic Cancer Models
- Zebrafish Retinoblastoma Models
- Zebrafish Rhabdomyosarcoma Models
- Zebrafish Thyroid Cancer Models
Zebrafish Metabolic Disease Models
- Zebrafish Diabetes Models
- Zebrafish Lysosomal Storage Disease Models
- Zebrafish Obesity Models
- Zebrafish Uremic Toxicity Models
Metabolic diseases are diseases caused by metabolic problems, including metabolic disorders and excessive metabolism. The etiology of metabolic diseases is complex, insidious and difficult to cure, mainly including obesity, diabetes, uremia, fatty liver, osteoporosis, atherosclerotic cardiovascular and cerebrovascular diseases, and metabolic-related cancers. The disease has the characteristics of one person suffering from multiple metabolic diseases, which makes the prognosis of the patient worse.
Zebrafish is a well-established model system for developmental biology, human genetics, and human disease, and it occupies an important position in developmental biology and disease modeling. The zebrafish is a vertebrate that is genetically, anatomically and physiologically highly similar to humans. Zebrafish are prolific, easy to maintain in large numbers, and have relatively short generation times, allowing for simple genetic and chemical genetic screens. The external development of zebrafish facilitates embryonic and genetic manipulation, and the optical transparency of its embryos allows for time-lapse real-time imaging. While zebrafish have traditionally been used in developmental biology, zebrafish have recently been used to study metabolic diseases.
Our Zebrafish Metabolic Disease Models
We establish a series of zebrafish models to study diabetes, including induced zebrafish diabetes model, targeted gene ablation zebrafish diabetes model, transgenic zebrafish diabetes model and mutant zebrafish diabetes model. Our rich and diverse zebrafish model of diabetes provides special advantages for the study of metabolic diseases, and we are committed to advancing your understanding of the mechanisms of diabetes through this model and providing new targets for diabetes treatment.
We develop a series of zebrafish models to study obesity, including food-induced zebrafish obesity models, transgenic zebrafish obesity models, and mutant zebrafish obesity models. Our zebrafish models have very high utility in mechanistic studies, drug testing and drug discovery in obesity and lipid metabolism, and we aim to help you uncover the anti-obesity activity of your drug candidates.
Zebrafish Uremic Toxicity Models
We have long experience in establishing preclinical zebrafish models of uremia. We can provide customized zebrafish uremic model construction services to monitor the effects of various compounds on the zebrafish uremic model. We aim to advance your uremic toxicity mechanism research and preclinical drug discovery with this model.
Zebrafish Lysosomal Storage Disease Models
Our zebrafish model can be classified into eight diseases, including sphingolipidosis, mucolipidosis, neuronal ceroid lipofuscinosis, integral membrane protein disease, glycogen storage disease, glycoproteinosis, Mucopolysaccharidosis and disorders of lysosome-associated organelles. We aimed to screen potential therapeutics for lysosomal storage diseases by zebrafish models to provide valuable insights into the pathogenesis of a range of zebrafish lysosomal storage diseases.
Advantages
- Easily monitor the progression of the disease
- Multiple induction models
- Mass mutagenesis
- High-throughput gene/drug screening
Creative Biogene has the expertise and experience to help you evaluate the therapeutic potential of compounds for metabolic diseases. Contact us today to discuss your goals and how we can achieve them.
References
- Zang L, et al. Zebrafish as a Model for Obesity and Diabetes. Frontiers in cell and developmental biology. 2018, 6:91.
- Anderson JL, et al. Zebrafish lipid metabolism: from mediating early patterning to the metabolism of dietary fat and cholesterol. Methods Cell Biol. 2011,101, 111–141.
- Biemar F, et al. Pancreas development in zebrafish: early dispersed appearance of endocrine hormone expressing cells and their convergence to form the definitive islet. Dev. Biol. 2011,230, 189–203.
- Capiotti KM, et al. Persistent impaired glucose metabolism in a zebrafish hyperglycemia model. Comp. Biochem. Physiol. B Biochem. Mol. Biol. 2014,171, 58–65.
For research use only. Not intended for any clinical use.
