- Zebrafish Germ Cell Tumor Models
- Zebrafish Intestinal Cancer Models
- Zebrafish Intrahepatic Cholangiocarcinoma Models
- Zebrafish Liver Cancer Models
- Zebrafish Melanoma Models
- Zebrafish Neurofibromatosis Type 1 Models
- Zebrafish Pancreatic Cancer Models
- Zebrafish Retinoblastoma Models
- Zebrafish Rhabdomyosarcoma Models
- Zebrafish Thyroid Cancer Models
Zebrafish Infectious Disease Models
- Zebrafish COVID-19 Models
- Zebrafish Hepatitis C Models
- Zebrafish Herpesvirus Infection Models
- Zebrafish Influenza Infection Models
- Zebrafish Tuberculosis Models
- Zebrafish Shigella Infection Models
In recent years, zebrafish has developed into an important surrogate for mammalian models for studying host-pathogen interactions. Because zebrafish lack a functional adaptive immune response during the first 4-6 weeks of development, they rely on the innate immune response to protect against injury and infection. At this early stage of development, we can study the mechanisms of infection and inflammation caused by the innate immune response without complications from the adaptive immune response.
The zebrafish possesses several inherent features that make it an attractive choice for studying host-pathogen interactions, including extensive sequence and functional conservation with the human genome, optical clarity in larvae (contributing to host cell-microbe interactions) high-resolution visualization), fully sequenced and annotated genomes, powerful forward and reverse genetic tools and technologies (e.g., CRISPR-Cas9 and TALEN), and amenity for chemical studies and screening.
Our Zebrafish Infectious Disease Models
Zebrafish Herpesvirus Infection Models
We have developed a range of zebrafish herpesvirus infection models, and we can help you through live imaging to study many aspects of HSV infection, such as host cell tropism, disease clinicopathology and associated inflammation, and immune response to infection. We can even help you screen for anti-inflammatory drugs that alter or block specific pathways through the identification of cytokine-specific signals during viral infection.
Our zebrafish Hepatitis C models can partially mimic HCV activity in human liver, inducing gene expression changes similar to those in human hepatocytes. Our models can be used to study HCV replication mechanisms, the pathology of HCV infection in the liver and to evaluate anti-HCV drugs or drug candidates.
Our zebrafish TB models facilitate more detailed dissection of effective immune responses and bacterial confrontation strategies at each stage of infection, and can also be used to supplement human patient data to identify reliable biomarkers for diagnosing different stages of TB thing. The models are viable tools for screening anti-TB drugs as well as for early vaccine development.
Zebrafish Shigella Infection Models
Our zebrafish shigella infection models have hallmarks of induction of human shigellosis, including inflammation and macrophage death. Our dedication to assisting you in discovering molecular determinants and events of cellular immunity to Shigella infection in vivo through this model provides a fundamental advance in your understanding of autophagy and inflammation.
Our zebrafish knot influenza model recapitulates clinical symptoms of human influenza infection in both gross pathology and histopathology. We aim to use this model to screen you for potential anti-influenza drugs, providing valuable insights into host-pathogen interactions across a range of infectious diseases.
Our zebrafish model can serve as an excellent model to study the pathophysiological effects of SARS-CoV-2 infection on the sense of smell, nervous system, cardiovascular system, and kidneys. We can genetically manipulate zebrafish to gain or lose function of countless proteins to help you characterize the dynamics and dynamics of SARS-CoV-2.
Advantages
- Optical accessibility for non-invasive live imaging
- Suitable for generation of fluorescent transgenic lines and targeted genetic manipulation
- Cost-effective high-throughput screening
- Availability of transgenic lines that label immune cells such as neutrophils
Creative Biogene has much experience to help you evaluate the therapeutic potential of compounds for infectious diseases. Contact us today to discuss your goals and how we can achieve them.
References
- Sullivan C, et al. Infectious disease models in zebrafish. Methods Cell Biol. 2017, 138:101-136.
- Sullivan C, et al. Zebrafish as a model for infectious disease and immune function. Fish Shellfish Immunol. 2008, 25(4):341-50.
- van der Sar AM, et al. A star with stripes: zebrafish as an infection model. Trends Microbiol. 2004, 12(10):451-457.
For research use only. Not intended for any clinical use.
