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Looking for a reliable partner to help you accelerate your cosmetic declaration process? Look no further than the Creative Biogene. Our team of experienced scientists leverages advanced technology to offer a comprehensive range of cosmetic efficacy evaluation services. With our services, you can significantly speed up your product development and get your cosmetics to market faster.
The zebrafish (Danio rerio) has become a popular vertebrate model to study for various types of research because of a combination of genetic, physical, and economic factors. With the development of scientific research methods, the zebrafish model provides a valid, whole living organism alternative to costly mammalian in vivo methods.
Zebrafish has emerged as a crucial model organism for medical research. Various studies have demonstrated that the epidermis of both zebrafish and human adult skin is multi-layered and includes a basal membrane (bm) as well as an underlying dermis containing collagen (col) fibers. This similarity suggests that zebrafish is an ideal candidate for skin-related research.
Fig. 1 Comparison between zebrafish and human skin
The main advantages you can achieve by using zebrafish embryos for cosmetic efficacy evaluation are as follows:
Zebrafish are widely used in scientific research for their genetic homology with humans (87% of the genome share). Moreover, the skin structure and function of zebrafish are remarkably similar to that of humans, making them an important model organism for evaluating cosmetic efficacy.
Zebrafish experiments can be completed within a relatively short time frame of 2 to 72 hours, with a sample dosage at the mg level. This not only saves time and cost in preparing cosmetic and raw material samples but also overcomes the limitations of conventional mammalian in vivo experiments, such as longer cycle times and higher costs.
Zebrafish embryos are transparent, and physiological changes in the skin, such as melanogenesis, and oxidative stress, can be directly observed under a microscope, or through phenotype analysis techniques, such as fluorescent imaging.
Zebrafish is a unique vertebrate model due to their small size and large numbers, which make them ideal for microtiter plate high content, high throughput, and fully automated analysis. This unique characteristic makes them the perfect choice for conducting early and large-scale high-throughput screening of cosmetic ingredient and formulation combinations.
Most of our research is conducted with zebrafish embryos before 5 days post fertilization, in compliance with the guidelines established in the 2010 European Commission Directive.
Creative Biogene provides a full range of efficacy evaluation for cosmetics, covering all major cosmetic categories.
If you are interested in our services, please do not hesitate to contact us at any time or submit an inquiry to us directly. We are looking forward to cooperating with you.
References
For research use only. Not intended for any clinical use.
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