Custom Contract Services

Zebrafish Genome Editing Services

The use of genetically modified zebrafish has allowed the identification of new putative therapeutic drugs. Creative Biogene can offer multiple gene-editing services including but not limited to point mutations, knockout, short insertions, gene knock-in and conditional knock-in. Our service can significantly reduce your experiment time and can be tailored to different experimental requirements.

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Zebrafish Toxicity Assays

The zebrafish (Danio rerio) is a useful animal model system for studying cardiovascular development, genetics, and cardiotoxicity. Recently, abundant chemical and drug toxicity screening have been conducted using zebrafish embryos. Creative Biogene can utilize zebrafish models to help you explore reliable detection parameters for drug-induced toxicity evaluation. Our services can help you predict the safety of new compounds during drug development, and the results provide the basis for internal decision-making.

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Zebrafish Disease Models

The cloning of mutated genes screened for specific phenotypes in zebrafish has similarities in humans and thus serves as model for human disease and to study underlying mechanisms. Creative Biogene has established a wide range of working zebrafish models to support multiple therapeutic/disease areas. Our zebrafish models provide insight into the pathogenesis of human disease and the related drug discovery and toxicology, and to enable the evaluation of novel small-molecule inhibitors.

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Zebrafish High Throughput Screening

A pair of adult zebrafish can produce hundreds of eggs in a single clutch, and the resulting embryos and larvae are sufficiently small that they can be housed in 96-well or 384-well plates, allowing phenotypic analysis using high-throughput microscopy and behavioral analysis systems. Creative Biogene can provide zebrafish high throughput screening service that acquires images of zebrafish in focus from head to tail with a large field of view and screen thousands of compounds in just a few days.

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WHY ZEBRAFISH

SMALL SIZE

SMALL SIZE

Allow the parallel and reproducible testing of several drugs and dosages in simple multiwell plates.

FECUNDITY

FECUNDITY

Zebrafish reproduce quickly, producing 9,000 offspring in a lifetime.

TRANSLUCENT

TRANSLUCENT

Promote direct scoring of organ morphology, and cytological events.

SIMILARITY

SIMILARITY

Zebrafish are widely used in scientific research for their genetic homology with humans (87% of the genome share).

PHYSIOLOGY

PHYSIOLOGY

Zebrafish possess recognizable organ systems — livers, hearts, kidneys, pancreases and so on.

PHARMACOLOGY

PHARMACOLOGY

The conservation of pharmacological effect is high for the majority of drugs where the phenotypic correlation is rigorous.

COST-EFFECTIVE

COST-EFFECTIVE

Zebrafish maintenance costs are less than 1/1000th of mice maintenance costs.

3R

3R

From the point of the "3R", zebrafish can be used to replace the so-called higher vertebrates with a less evolve organism.

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