Zebrafish Basic Research
Zebrafish (Danio rerio) are increasingly used to address key questions raised in basic and applied research, including biomedicine, toxicology, environmental science, biotechnology and aquaculture etc. In recent years, the number of publications per year on zebrafish as a model for biomedical research has been significantly increased. More than 1000 laboratories use zebrafish as a research model all over the world.
(The number of publications in PubMed per year when searching with the keywords "zebrafish" and "Biomedical.")
Why Do Zebrafish Make Such Good Animal Models?
Although humans may seem to be extremely different than zebrafish, we are actually much more similar to them than you might think. Zebrafish possesses several obvious advantages over other vertebrate models:
The zebrafish is similar to humans anatomically and genetically. Approximately 80% of the genes involved in human diseases have an equivalent in Zebrafish.
Due to the simplicity of their natural habitat, it is much easier to maintain them in a laboratory than to simulate the conditions essential for mammals. Their short generation time of 3-5 months improves the rate of experimental progress.
Adult zebrafish breed readily and can produce 50 to 300 eggs at a time.
The one-cell-stage fertilized eggs can be easily injected with DNA or RNA to permanently modify their genetic makeup to generate transgenic or knock-out zebrafish lines.
Zebrafish embryos and larvae are transparent and together with their small size allow the live observation of dynamic developmental and regenerative processes. Their transparency also enables the visualization of fluorescently labeled tissues in transgenic zebrafish embryos.
Because of the small size of the larvae, high-throughput screening of candidate compounds can be easily performed.
Creative Biogene, a Biotech Contract Research Organization (CRO) specialized in zebrafish services, provides professional services and technical support to customers worldwide. Our comprehensive zebrafish basic research services cover zebrafish gene clone, gene expression analysis, gene editing, microinjection, genotyping, health monitoring and high-throughput screen services, etc. We can also provide customized zebrafish services according to the specific requirements.
Zebrafish Gene Cloning Services
In recent years, we have cloned out thousands of zebrafish genes from cDNA libraries and zebrafish tissue.
Zebrafish Gene Expression Analysis
Creative Biogene can offer comprehensive zebrafish gene expression analysis services to help you get insights into expression information and perform rich analysis data.
Zebrafish Genotyping Service
We can provide rapid, high-throughput zebrafish genotyping, point mutation genotyping, and zygosity testing for embryos and adult fish.
Zebrafish Health Monitoring Services
We have developed a comprehensive array of diagnostic services to proactively monitor the health of your zebrafish colonies.
Zebrafish High-throughput Screen Services
Creative Biogene can create and implement custom, zebrafish high content imaging-based phenotypic assays.
References
- Teame T, et al. The use of zebrafish (Danio rerio) as biomedical models. Animal Frontiers, 2019, 9(3): 68-77.
- Saleem S, Kannan R R. Zebrafish: an emerging real-time model system to study Alzheimer’s disease and neurospecific drug discovery. Cell death discovery, 2018, 4(1): 1-13.
For research use only. Not intended for any clinical use.
