Principal Scientist, Discovery Toxicology

The ideal candidate will have a proven track record in prominent roles supporting cross-functional Discovery teams. She/he is able to leverage their deep insights into cellular and pathway mechanisms, coupled with knowledge of toxicology in order to provide expertise and direction to improve the quality of therapeutics.

Key Responsibilities:

• Provide pharmaceutical drug project teams with expert advice and direction to improve the quality of therapeutics selected for further development based on proactive risk assessment of target- and chemotype-related toxicities
• Develop comprehensive target safety reviews with risk mitigation plans for early drug discovery project teams based on literature, bioinformatics, and other predictive tools.
• Apply state of the art in silico, in vitro, and in vivo de-risking strategies to aid in the selection and optimization of large and small molecule therapeutics, as well as new therapeutic modalities.
• Lead the development of early hypothesis-driven investigation into mechanisms of toxicity for the proactive management of potential safety liabilities and communication of impact to teams.

Basic Qualifications:

• Ph.D. in a life science field and 5+ years of experience working at pharmaceutical companies.
• Passion to decrease safety-related attrition in drug discovery.
• Demonstrated experience and ability to work effectively in a matrix, global environment as part of a multidisciplinary team.
• Broad scientific knowledge including pharmacology, toxicology, cell/molecular biology, physiology and biochemistry.
• Experience in drug development across mixed modalities and extensive knowledge in immunology, gastrointestinal, and/or neuroscience is desired.
• Strong interpersonal and organizational skills.
• Excellent oral and written communication skills.

Creative Biogene is an equal opportunity employer and does not discriminate against otherwise qualified applicants on the basis of race, color, creed, religion, ancestry, age, sex, marital status, national origin, disability or handicap, or veteran status.