Freckle Removal Efficacy Evaluation
Creative Biogene Zebrafish Platform is a state-of-the-art solution that offers comprehensive efficacy evaluation services of freckle removal products, allowing for better product development. Our platform is designed to provide a wide range of efficacy evaluation services that are tailored to meet the specific needs of your project. With a highly skilled research team and cutting-edge technology, Creative Biogene can deliver corresponding solutions that are accurate, reliable, and cost-effective. Whether you are looking to develop new products or enhance existing ones, our zebrafish platform provides a valuable resource for evaluating the efficacy of your cosmetics, helping you to achieve your goals with confidence.
Freckles, those tiny, flat, brownish spots that appear on the skin, are caused by an increase in the amount of melanin pigment in the skin cells. They usually emerge on the face, arms, and shoulders, and can be a source of cosmetic concern for some people. Undesirable freckle problems make freckle removal products with safety and effectiveness a continuous challenge and interest in the cosmetic industry.
Danio rerio, commonly known as zebrafish, is a well-studied model organism characterized by its small size, rapid maturation, short life span, large number of offspring, and easy manipulation. One of the most interesting features of zebrafish is that it is transparent during the early stages of development. Melanin can be observed on the zebrafish surface, allowing simple observation of the pigmentation process.
Our Zebrafish-based Freckle Removal Efficacy Evaluation
During the larval phase, zebrafish display translucent skin, enabling precise observation of melanin production on their body surface. At Creative Biogene, we assess the effectiveness of freckle removal by meticulously analyzing melanin distribution. Initially, zebrafish embryos undergo treatment with your cosmetic products and are then incubated for a specific duration. Subsequently, we meticulously examine melanin formation in the treated zebrafish embryos under a microscope. Finally, we utilize advanced image analysis software to quantify the melanin content, thereby determining the inhibitory effect on melanin production.
Fig. 1 Workflow of our zebrafish-based freckle removal evaluation
Fig. 2 Representative images of zebrafish embryos that were treated with 100 μg/mL of SMCE, SMHF, SMEAF, and SMWF for 24 h. PTU is the positive control in this assay (n = 50).
Over the years, Creative Biogene Zebrafish Platform has meticulously conducted comprehensive and in-depth cosmetic efficacy evaluation. Our unwavering commitment is to provide precise, dependable results, catering to clients globally. If you are interested in our services, please do not hesitate to contact us at any time or submit an inquiry to us directly. We are looking forward to cooperating with you.
References
- Qu, J.; et al. Zebrafish in dermatology: a comprehensive review of their role in investigating abnormal skin pigmentation mechanisms. Frontiers in Physiology, 2023, 14.
- Mahendra, C.K.; et al. The anti-melanogenic properties of Swietenia macrophylla king. Biomedicine & Pharmacotherapy, 2023, 162: 114659.
For research use only. Not intended for any clinical use.
