Zebrafish Toxicity Testing
Comprehensive Safety Assessment for Preclinical Research
Support your safety assessment with customized zebrafish toxicity studies for organ specific toxicity, neurotoxicity, developmental toxicity, immunotoxicology, endocrine disruption, ecotoxicology and much more. Our flexible testing solutions speed up early safety assessment in a variety of research applications.
Speed up safety evaluation using zebrafish toxicity models
Safety assessment is an essential part of preclinical research that helps to identify potential toxic liabilities before compounds move forward to expensive development stages. Zebrafish are a well-established vertebrate model with conserved organ systems and physiological pathways that are used to evaluate compound toxicity in a wide range of therapeutic and chemical applications. Their unique biological properties enable integrated assessment of multiple toxicity endpoints in a single organism and allow for efficient study timelines and scalable experimental designs.
Our zebrafish toxicity platform offers a complete safety evaluation service including organ-specific toxicity, developmental and reproductive toxicity, neurotoxicity, immunotoxicology, endocrine and metabolic toxicity, and environmental toxicity. Studies are designed to address project goals, target organs, exposure regimens and analytical end points to generate high-quality data for early hazard identification and mechanistic toxicology research.
Zebrafish Toxicity Service Offerings
Organ-Specific Toxicity Assessment
Evaluate structural and functional toxicity of major organ systems (cardiovascular, hepatic, renal, digestive, vascular, muscular, ocular and auditory). These studies help in identifying target organ toxicity and in characterizing tissue-specific adverse effects.
Immunotoxicology Assays
Assess immune responses, inflammation and innate immune function induced by compounds to evaluate potential immunotoxicity effects and immune-related safety risks.
Neurotoxicity Assessment
Characterize the effects of compounds on neurological function and nervous system development using integrated behavioral, developmental and neurobiological analyses.
Developmental & Reproductive Toxicity
Evaluate the effects of test articles on embryonic development, survival, morphology and genetic stability in support of early developmental safety assessment.
Endocrine & Metabolic Toxicity
Assess hormone regulated pathways and metabolism related toxicological responses to investigate endocrine signaling and disruption of metabolic homeostasis.
Ecotoxicity Assays
Support environmental safety assessment through assessment of biological effects of environmental pollutants, industrial chemicals, nanomaterials and other emerging contaminants in aquatic systems.
Applications
Our zebrafish toxicity testing services are useful for safety assessment for a wide range of research and product development programs including:
Drug Discovery & Preclinical Development
Lead optimization, early toxicity screening and safety profiling
Biotechnology & Advanced Therapeutics
Safety assessment of biologics, peptides, nucleic acid therapeutics and cell-based products.
Chemical Safety Assessment
Toxicity testing of industrial chemicals, specialty chemicals and research compounds
Cosmetics & Personal Care
Safety assessment of cosmetic ingredients and formulations for consumer products.
Agricultural products
Toxicological evaluation of pesticides, agrochemicals, veterinary products and feed additives.
Environmental Toxicology
Risk assessment of aquatic pollutants, endocrine disrupting chemicals and nanomaterials.
Academic Research
Bespoke toxicity studies for mechanistic research and biomarker identification.
Get Started with Your Toxicity Study
Work alongside our scientists to develop customized zebrafish toxicity studies from early safety screening to mechanistic toxicology evaluation to meet your research goals.
