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Optical imaging is critical for zebrafish-based research, as it allows for direct visualization of biological processes in living vertebrate models. Depending on the study design, zebrafish imaging can be used to visualize organ development, cellular localization, reporter activity, tumor load, vascular creation, immune cell movement, infection progression, and compound-induced phenotypic alterations.
Our imaging services are designed to provide not only high-quality images, but also quantitative endpoints such as fluorescence intensity, bioluminescent signal, tumor area, vessel length, cell distribution, organ volume and time-course signal changes.
This makes zebrafish optical imaging particularly useful for studies that require both visual evidence and quantitative biological readouts.
The confocal microscope enables high resolution optical sectioning for thorough visualization of zebrafish tissues, organs and fluorescently labelled cells. It is particularly useful for studies requiring signal localization, or tissue-level structural analysis.
Light-sheet microscopy allows fast three-dimensional imaging of zebrafish embryos and larvae with less phototoxicity. This is particularly useful for live-imaging, whole-embryo imaging and dynamic developmental analyses.
Fluorescence imaging is commonly employed in zebrafish models to visualize fluorescent proteins, labelled cells, fluorescent dyes, and transgenic reporter lines. It enables both qualitative visualization and quantitative study of fluorescence-based biological data.
Bioluminescence imaging offers a sensitive and low-background method for detection of luciferase-based signals. It is useful for monitoring biological processes that change their signal intensity over time, such as tumor load, infection progression, reporter activity, and therapy response.
Our advanced optical imaging services can be adapted to a range of zebrafish models and experimental designs, including:
Drug Discovery
Evaluate compound effects on reporter activity, tumor burden, vascular development, cell migration, and disease-related phenotypes.
Toxicology
Visualize developmental defects, organ-specific abnormalities, altered signals, and tissue damage.
Disease Model Validation
Confirm disease-associated imaging phenotypes and assess treatment or genetic rescue effects.
Gene Function Studies
Link gene perturbation to changes in reporter activity, tissue development, cell behavior, or organ morphology.
Oncology, Angiogenesis, Infection & Inflammation
Quantify tumor growth, vessel formation, pathogen burden, and immune cell recruitment.
Project deliverables can be customized according to the study scope and may include:
Data can be delivered in formats suitable for internal decision-making, publication preparation, follow-up assay design, or preclinical study planning.
What are zebrafish optical imaging services used for?
Which imaging modality should I use?
Can fluorescence signals be quantified?
Can imaging be coupled with other zebrafish assays?
Whether you need high-resolution microscopy, 3D live imaging, fluorescent reporter quantification, bioluminescent signal detection, or image-based phenotype analysis, our zebrafish CRO team can help design an imaging strategy tailored to your research goals.
For research use only. Not intended for any clinical use.
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